Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.
Function
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.
See also
- Myeloid tissue
References
Further reading
External links
- HOXB5 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P02833 (Drosophila melanogaster Homeotic protein antennapedia) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
